Öz
Arka plan/amaç: Bu çalışmanın temel amacı, dekspantenol içeren bir nemlendirici krem hazırlamak ve değerlendirmektir. Gereçler ve yöntemler: Bu çalışmada, bağımsız değişkenin değişen konsantrasyonlarının fiziksel görünüm, pH, elektriksel iletkenlik, viskozite ve sürülebilirlik Cera alba ve Stearik asidin çeşitli eksipiyanlarla farklı kombinasyonları ile farklı formülasyonlar hazırlandı. Geliştirilen formülasyonlar QbD yaklaşımı ile incelenmiştir. "Tasarımla kalite" olarak bilinen bir süreç, ürünün önceden belirlenmiş kalitesini garanti etmek için farmasötiklerin planlanması, geliştirilmesi ve üretiminde istatistiksel, analitik ve risk yönetimi tekniklerini kullanır.
Sonuçlar: QbD çalışmalarına göre Tasarım Alanı optimum formüller için verilmiştir. Ana etkiler ve tepkiler için model denklemleri oluşturulduktan sonra, stearik asit ve cera alba içeren çeşitli krem formülasyonları, sürülebilirlik, viskozite ve elektrik iletkenliğine dayalı olarak optimize edildi.
Sonuç: Sonuç olarak, bu araştırma çalışmasında elde edilen farklı formülasyonların sonuçları, belirli oranda Cera alba ve Stearik asit içeren bir nemlendirici kremin gelecek vaat eden bir potansiyele sahip olduğunu açıkça göstermiştir. Bu nedenle, kozmetik faydalarını kazanmak için nemlendirici kreme oranlarda Cera alba ve Stearik asit dahil edilir.
Anahtar Kelimeler
Kaynakça
- Falcetta, P., Benelli, E., Molinaro, A., Di Cosmo, C., Bagattini, B., Del Ghianda, S., ... & Tonacchera, M. (2021). Effect of aging on clinical features and metabolic complications of women with polycystic ovary syndrome. Journal of Endocrinological Investigation, 44(12), 2725-2733.
- Fux Otta, C., Wior, M., Iraci, G. S., Kaplan, R., Torres, D., Gaido, M. I., & Wyse, E. P. (2010). Clinical, metabolic, and endocrine parameters in response to metformin and lifestyle intervention in women with polycystic ovary syndrome: a randomized, double-blind, and placebo control trial. Gynecological Endocrinology, 26(3), 173-178.
- Giallauria, F., Palomba, S., Maresca, L., Vuolo, L., Tafuri, D., Lombardi, G., ... & Francesco Orio. (2008). Exercise training improves autonomic function and inflammatory pattern in women with polycystic ovary syndrome (PCOS). Clinical endocrinology, 69(5), 792-798.
- Kabakchieva, P., Georgiev, T., Gateva, A., Hristova, J., & Kamenov, Z. (2021). Polycystic ovary syndrome and (pre) osteoarthritis: assessing the link between hyperandrogenism in young women and cartilage oligomeric matrix protein as a marker of cartilage breakdown. Clinical Rheumatology, 40, 4217-4223.
- Karavani, G., Chill, H. H., Schachter-Safrai, N., Lomnitz, G., Gillis, D., & Bauman, D. (2021). Gonadotropin releasing hormone analogue treatment of central precocious puberty is not associated with altered prevalence of polycystic ovary syndrome: a single center cohort study. Clinical Diabetes and Endocrinology, 7, 1-6.
- Karimi, E., Moini, A., Yaseri, M., Shirzad, N., Sepidarkish, M., Hossein-Boroujerdi, M., & Hosseinzadeh-Attar, M. J. (2018). Effects of synbiotic supplementation on metabolic parameters and apelin in women with polycystic ovary syndrome: a randomised double-blind placebo-controlled trial. British Journal of Nutrition, 119(4), 398-406.
- Kayacık Günday, Ö., Özdemir Erdoğan, M., Pehlivan, A., & Yılmazer, M. (2022). The effect of metformin treatment on leukocyte telomere length in patients with polycystic ovary syndrome: a prospective case–control study. Journal of Assisted Reproduction and Genetics, 39(9), 2153-2161.
- Mizgier, M., Jarząbek-Bielecka, G., Wendland, N., Jodłowska-Siewert, E., Nowicki, M., Brożek, A., ... & Opydo-Szymaczek, J. (2021). Relation between inflammation, oxidative stress, and macronutrient intakes in normal and excessive body weight adolescent girls with clinical features of polycystic ovary syndrome. Nutrients, 13(3), 896.
- Naumova, I., Castelo-Branco, C., Kasterina, I., & Casals, G. (2021). Quality of life in infertile women with polycystic ovary syndrome: a comparative study. Reproductive Sciences, 28(7), 1901-1909.
- Nekooi, M., Bazarganipour, F., Zoladl, M., Heshmat, R., Aramesh, S., & Hosseini, N. (2022). Effect of Acupressure on Health-Related Quality of Life in Patients with Polycystic Ovarian Syndrome: A Randomized Clinical Trial. Evidence-Based Complementary and Alternative Medicine, 2022.
- Robinson, S., Kiddy, D., Gelding, S. V., Willis, D., Niththyananthan, R., Bush, A., ... & Franks, S. (1993). The relationship of insulin insensitivity to menstrual pattern in women with hyperandrogenism and polycystic ovaries. Clinical endocrinology, 39(3), 351-355.
Öz
Background/aim: The main purpose of this work was to prepare and evaluate a moisturizing cream containing dexpanthenol. Materials and methods: In this study, several cream formulations were prepared using the oil-in-water (O/W) emulsion technique to investigate the effect of varying concentrations of the independent variable on the physical appearance, pH, electrical conductivity, viscosity and spreadability. Different formulations were prepared with different combinations of Cera alba and Stearic acid with various excipients. The developed formulations were examined with the QbD approach. A process known as "quality by design" uses statistical, analytical, and risk-management techniques in the planning, development, and production of pharmaceuticals to guarantee the predetermined quality of the product.
Results: According to the QbD studies, the Design Space is given for optimum formulae. After establishing the model equations for the main effects and responses, various cream formulations containing stearic acid and cera alba were optimized based on spreadability, viscosity, and electrical conductivity.
Conclusion: In conclusion, the outcomes of different formulations obtained in this research study clearly showed that a moisturizing cream containing a certain ratio of Cera alba and Stearic acid have an up-and-coming potential. Therefore, proportions of Cera alba and Stearic acid are included in the moisturizing cream to win its cosmetic benefits.
Anahtar Kelimeler
Kaynakça
- Falcetta, P., Benelli, E., Molinaro, A., Di Cosmo, C., Bagattini, B., Del Ghianda, S., ... & Tonacchera, M. (2021). Effect of aging on clinical features and metabolic complications of women with polycystic ovary syndrome. Journal of Endocrinological Investigation, 44(12), 2725-2733.
- Fux Otta, C., Wior, M., Iraci, G. S., Kaplan, R., Torres, D., Gaido, M. I., & Wyse, E. P. (2010). Clinical, metabolic, and endocrine parameters in response to metformin and lifestyle intervention in women with polycystic ovary syndrome: a randomized, double-blind, and placebo control trial. Gynecological Endocrinology, 26(3), 173-178.
- Giallauria, F., Palomba, S., Maresca, L., Vuolo, L., Tafuri, D., Lombardi, G., ... & Francesco Orio. (2008). Exercise training improves autonomic function and inflammatory pattern in women with polycystic ovary syndrome (PCOS). Clinical endocrinology, 69(5), 792-798.
- Kabakchieva, P., Georgiev, T., Gateva, A., Hristova, J., & Kamenov, Z. (2021). Polycystic ovary syndrome and (pre) osteoarthritis: assessing the link between hyperandrogenism in young women and cartilage oligomeric matrix protein as a marker of cartilage breakdown. Clinical Rheumatology, 40, 4217-4223.
- Karavani, G., Chill, H. H., Schachter-Safrai, N., Lomnitz, G., Gillis, D., & Bauman, D. (2021). Gonadotropin releasing hormone analogue treatment of central precocious puberty is not associated with altered prevalence of polycystic ovary syndrome: a single center cohort study. Clinical Diabetes and Endocrinology, 7, 1-6.
- Karimi, E., Moini, A., Yaseri, M., Shirzad, N., Sepidarkish, M., Hossein-Boroujerdi, M., & Hosseinzadeh-Attar, M. J. (2018). Effects of synbiotic supplementation on metabolic parameters and apelin in women with polycystic ovary syndrome: a randomised double-blind placebo-controlled trial. British Journal of Nutrition, 119(4), 398-406.
- Kayacık Günday, Ö., Özdemir Erdoğan, M., Pehlivan, A., & Yılmazer, M. (2022). The effect of metformin treatment on leukocyte telomere length in patients with polycystic ovary syndrome: a prospective case–control study. Journal of Assisted Reproduction and Genetics, 39(9), 2153-2161.
- Mizgier, M., Jarząbek-Bielecka, G., Wendland, N., Jodłowska-Siewert, E., Nowicki, M., Brożek, A., ... & Opydo-Szymaczek, J. (2021). Relation between inflammation, oxidative stress, and macronutrient intakes in normal and excessive body weight adolescent girls with clinical features of polycystic ovary syndrome. Nutrients, 13(3), 896.
- Naumova, I., Castelo-Branco, C., Kasterina, I., & Casals, G. (2021). Quality of life in infertile women with polycystic ovary syndrome: a comparative study. Reproductive Sciences, 28(7), 1901-1909.
- Nekooi, M., Bazarganipour, F., Zoladl, M., Heshmat, R., Aramesh, S., & Hosseini, N. (2022). Effect of Acupressure on Health-Related Quality of Life in Patients with Polycystic Ovarian Syndrome: A Randomized Clinical Trial. Evidence-Based Complementary and Alternative Medicine, 2022.
- Robinson, S., Kiddy, D., Gelding, S. V., Willis, D., Niththyananthan, R., Bush, A., ... & Franks, S. (1993). The relationship of insulin insensitivity to menstrual pattern in women with hyperandrogenism and polycystic ovaries. Clinical endocrinology, 39(3), 351-355.
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Konular | Eczacılık ve İlaç Bilimleri |
| Bölüm | Research Article |
| Yazarlar | |
| Yayımlanma Tarihi | 30 Nisan 2023 |
| Kabul Tarihi | 17 Nisan 2023 |
| Yayımlandığı Sayı | Yıl 2023 Cilt: 5 Sayı: 1 |
